The main use of BCG is for vaccination against tuberculosis. BCG vaccine can be administered after birth intradermally. BCG vaccination is recommended to be given intradermally. Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is a leading cause of human disease and death, particularly in developing countries. Emerging mycobacterial drug resistance is further complicating the situation. After decades of steady decline, the incidence of TB is also increasing in industralized countries, mainly as the result of outbreaks in particularly vulnerable groups. BCG vaccine has a documented protective effect against meningitis and disseminated TB in children.